Abstract
Abstract The sera of two hundred and fifty-nine individuals have been investigated for the presence of the Down syndrome protein (DSP) by a modified immunoelectrophoretic procedure. The results showed that 66.25 percent of the eighty couples with Down syndrome (DS) affected children were DSP positive which was well in accordance with the reported occurrence of nondisjunction at meiosis I from various research groups (53.8% to 90.3%). Furthermore, from the study of 56 pure meiotic nondisjunction trisomy 21 cases, 40 cases (71.4%) showed that the DSP was present in the sera of the parents who were responsible for the extra chromosome in the DS affected children. This evidence strongly supported the original hypothesis by Miles that the presence of the DSP was associated with non disjunction occurring during the first meiotic divsion.
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