Abstract
contrast sensitivity (mean deviation, MD; pattern standard deviation, PSD), 110 threshold measures from 55 retinal regions of each eye, and demographic and cognitive performance variables were compared between groups using ANCOVA, covaried for age at exam, gender, and years of education. The relationships between global GMD, MD, and PSD were assessed using SPM5. Results: Significant differences across groups were detected in FDT-2 measures of overall and local contrast sensitivity, including both MD and PSD, and in 36 right eye retinal regions and 48 left eye retinal regions (p < 0.05 to p < .0001, Figure 1). AD and MCI patients demonstrated the greatest reduction in contrast sensitivity relative to HCs, with CC participants showing an intermediate level of impairment. MD and PSD were significantly related to hippocampal GMD in the left and bilateral hippocampi, respectively (p < 0.01 (unc.), Figure 2). Conclusions: Contrast sensitivity, as measured by the FDT-2 system, is reduced in patients with AD and MCI and may represent a novel and complementary biomarker for detecting and monitoring AD-related neurodegeneration. IC-P-007 CORRELATION OF THE AD8: AN INFORMANTBASED DEMENTIA SCREENING TOOL WITH AMYLOID IMAGING AND CSF BIOMARKERS OF ALZHEIMER DISEASE
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