Abstract
contrast sensitivity (mean deviation, MD; pattern standard deviation, PSD), 110 threshold measures from 55 retinal regions of each eye, and demographic and cognitive performance variables were compared between groups using ANCOVA, covaried for age at exam, gender, and years of education. The relationships between global GMD, MD, and PSD were assessed using SPM5. Results: Significant differences across groups were detected in FDT-2 measures of overall and local contrast sensitivity, including both MD and PSD, and in 36 right eye retinal regions and 48 left eye retinal regions (p < 0.05 to p < .0001, Figure 1). AD and MCI patients demonstrated the greatest reduction in contrast sensitivity relative to HCs, with CC participants showing an intermediate level of impairment. MD and PSD were significantly related to hippocampal GMD in the left and bilateral hippocampi, respectively (p < 0.01 (unc.), Figure 2). Conclusions: Contrast sensitivity, as measured by the FDT-2 system, is reduced in patients with AD and MCI and may represent a novel and complementary biomarker for detecting and monitoring AD-related neurodegeneration. IC-P-007 CORRELATION OF THE AD8: AN INFORMANTBASED DEMENTIA SCREENING TOOL WITH AMYLOID IMAGING AND CSF BIOMARKERS OF ALZHEIMER DISEASE
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
