CORRELATION OF TESTOSTERONE AND CORONARY ARTERY DISEASE IN YOUNG AGED MALES

Abstract

Introduction: Higher serum testosterone levels were thought to be harmful to the cardiovascular system. While few research have concluded low testosterone levels as risk factors for cardiovascular disease (CVD). We conducted a cross-sectional research study to see if there was a link between blood testosterone levels and the severity of coronary artery disease on angiography (CAD). Cardiovascular disease (CVD) is the largest cause of death worldwide, with coronary artery disease (CAD) being the main cause of death. Furthermore, CVD causes considerable morbidity and disability-adjusted life years lost (DALYS). Aim: Correlation of testosterone and coronary artery disease in young aged males. Material and Method: The study was conducted in the Department of General Medicine. It included 50 healthy male subjects and 50 CAD subjects of age 18 -45 years who visited the OPD of Dept. of Medicine. Result: In the study group as showed in Table 1, both groups were compared for Total cholesterol, triglycerides, HDL, VLDL and Testosterone levels. Low testosterone levels were statistically related with severity of CAD (P 0.05). Conclusion: Low testosterone levels, according to our findings, are an independent risk factor for coronary artery disease and endothelial dysfunction. To determine the role of testosterone as a modifiable risk factor, a randomised controlled trial of testosterone replacement in hypogonadal males and study of its impact on endothelial function, risk factors for cardiovascular disease, CAD development, and outcomes, is required. The current study is the first of its kind in Indian community, and it supports previous research on other populations. Pathogenetic and long-term clinical investigations are needed to elucidate the specific mechanism behind our findings and their therapeutic significance. Keywords: CAD, CVD, Testosterone, SHBG, HDL, LDL