Correlation of Subclinical Hypothyroidism in Cholelithiasis: A Case Control Study

Abstract

Gall stone disease is one of the most common cause for hospital admissions, with thyroid disorders being the most common endocrinopathy world wide. Aim: To establish correlation between subclinical hypothyroidism in the formation of gall stones and bile duct stones. Materials and Methods: Hospital based case control study on 400 patients in surgical OPD. S. TSH used for assesment of thyroid function and Cholelithiasis as diagnosed by ultrasound or suspected. Statistical: Categorical variables are expressed as Number and percentage of patients and compared using Pearson’s Chi Square test for Independence of Attributes/ Fisher’s Exact Test. Continuous variables are expressed as Mean, Median and Standard Deviation and compared using Mann-Whitney U test. Statistical software SPSS version 20 has been used. Result: 400 patients evaluated. Out of 400 there were 7 with low (<0.3 mIU/L), 232 with normal, 161 with high TSH (>3 mIU/L). The proportion of cholelithiasis among males and females 38 and 62 % respectively. Significantly larger proportions of patients in Cases (male = 55.26%; female = 54.03%) have High TSH than Control (male = 38.82%;female = 41.13%), p value < 0.001 i.e significant. Conclusion: There is an association between hypothyroidism and formation of gall stones.