Correlation of SMARCA4 rs1122608 and ZFHX3 rs2106261 polymorphisms with acute myocardial infarction susceptibility in Egyptian population

Abstract

ObjectivesOur objective is to assess SMARCA4 rs1122608 and ZFHX3 rs2106261 polymorphisms as risk factors for acute myocardial infarction (AM)I. BackgroundThe fact that there is documented familial clustering of myocardial infarction (MI) cases, shows that there is a genetic component to MI in addition to the traditional acquired risk factors. To our knowledge, this is the first study to evaluate the impact of participation of SMARCA4 and ZFHX3 polymorphisms in AMI patients in Egyptian population. Patients and methodsThis study was conducted on AMI patients (n = 100) and healthy controls (n = 100). SWI/SNF related, matrix associated, actin dependent regulator of chromatin A4(SMARCA4) (rs1122608) and Zinc Finger Homeobox 3 (ZFHX3) (rs 2,106,261) SNP assays were performed separately by real-time PCR for all participants. ResultsPatients with an acute myocardial infarction exhibited significantly higher levels of cardiac markers, total cholesterol, triglyceride, and low-density lipoprotein. The present work found considerably higher homozygous mutant T/T genotype and mutant T allele of SMARCA4 (rs1122608) in AMI patients than in healthy controls (p 0.001), which is confirmed under the dominant, over-dominant, and recessive mode of inheritance. Moreover, the results revealed that the TT genotype can increase the risk of AMI by OR (95% CI) [5.359(1.94014.81)], the T allele can also increase the risk of AMI by OR (95% CI) [4.472(2.797–7.151)]. Regarding the genotype and alleles distribution of ZFHX3 (rs 2,106,261), there was nonsignificant difference regard the genotypes TT, TC and CC between two studied groups which is confirmed under the dominant, over-dominant, and recessive mode of inheritance. ConclusionOur findings suggest that SMARCA4 (rs1122608) is associated with an increased risk of AMI in Egyptians.