CORRELATION OF SIZE AND VOLUME OF CT SCAN LESION WITH SYSTEMIC INFLAMMATORY RESPONSE IN ACUTE CEREBROVASCULAR ACCIDENTS

Abstract

Background Acute cerebrovascular accidents (CVA) are the leading cause of mortality and morbidity worldwide. CVA is now considered to produce an inammatory response in brain and periphery in form of rise in inammatory markers. CT scan head is an initial investigation of choice in acute cerebrovascular accidents (stroke). This study was done to correlate the size and volume of CT scan head lesion with inammatory response in acute cerebrovascular accidents. Methods Study was conducted in 90 patients of acute CVA admitted in LLR and associated hospitals, G.S.V.M. medical college Kanpur. All patients of CVA (stroke) fullling the Inclusion and exclusion criteria were enrolled in the study. CT scan head was done as an initial investigation to conrm the diagnosis. To assess the inammatory response Serum CRP (hs-CRP) level was measured by Turbidimetric immunoassay. Statistical analysis was done by using T test and chi square test. Results Our patients were mostly in the age group of 40-79 years with mean age 59 year with male predominance. CRP levels were found to be elevated statistically signicant in all types of CVA patients as compared to controls. There was signicant rise from rst day to third day (P<0.05). CRP was maximum in patients of cerebral infarction as compared to other types of stroke. Observation showed higher CRP level in patients with larger lesion in CT head. Mean CRP of expired patients was higher as compared to whole study group (P<0.05). Conclusions We concluded that CRP level was much elevated with increase in size and volume of lesion in CT head in patients of CVA indicating the magnitude of inammatory response, assessing severity and outcome