Correlation of Serum Uric Acid and Urine Uric Acid in Patients with Type 2 Diabetes Mellitus and Hypertension

Abstract

Aims and objectives: To estimate the proportion of Hyperuricemia in patients with type 2 Diabetes Mellitus and Hypertension patients and to assess the correlation of serum uric acid and urine uric acid. To assess the relationship between Urine Uric acid/ Creatinine ratio and subclinical Renal damage among these patients. Materials and methodology: This cross-sectional study was conducted in Sri Manakula Vinayagar Medical College and Hospital Puducherry during a period of 6 months. Adults more than or equal to 18 years of age with Type 2 Diabetes Mellitus and Hypertension were included and a total of 56 patients were recruited. Patients were randomly included based on the inclusion and exclusion criteria Results: Patients with Subclinical Renal damage were categorized and constitutes around 53.7%. Odds ratios on comparing the duration of Diabetes and Hypertension, shows inverse correlation with eGFR of both SRD and non-SRD patients (0.469,0.449 respectively) and with Urine Uric acid/ Creatinine ratio was found to have positive correlation (0.108 and 0.085). On comparing eGFR and Urine Uric acid/ Creatinine ratio of SRD and non-SRD patients, it showed positive correlation with value of 0.336. Conclusion: Lower eGFR was associated with higher levels of Serum Uric Acid and Fractional excretion of uric acid (FEUA), but lower uUA/Cr levels. Thus this study suggests that urinary Uric Acid excretion was significantly associated with the risk of Subclinical Renal Damage and Urinary Uric acid can be used as a simple, noninvasive marker for early detection of decreased renal function in otherwise healthy subjects. Keywords: Subclinical Renal Damage, Urinary Uric Acid, Fractional Excretion of Uric Acid