Correlation of serum thyroid-stimulating hormone with dyslipidemia in subjects with normal thyroid function

Abstract

Objective To explore the relationship between serum thyroid-stimulating hormone(TSH)and dyslipidemia. Methods A total of 1 512 inhabitants in Zhaiji community of Guiyang urban areas were investigated from November 2009 to February 2010 by adopting stratified cluster sampling method, and 1 428 subjects were included in the present study. All subjects were asked to fulfill the questionnaires and to pass a physical examination. The vein blood samples were taken for determination of serum TSH, fasting plasma glucose(FPG), insulin, as well as blood lipid levels. Results Triglyceride(TG), total cholesterol, high density lipoprotein cholesterol, and low density lipoprotein cholesterol levels were significantly increased in woman with subclinical hypothyroidism(SCH)compared to those with euthyroid(all P 0.05). The incidences of hypertriglyceridemia in the euthyroid group from quartile 1 to quartile 4 of TSH were 33.3%, 35.5%, 39.7%, and 44.0% respectively(P<0.05). Serum TG level was increased with TSH in woman and total subjects after adjustment for age, sex, body mass index(BMI), waist-hip ratio(WHR), and homeostasis model assessment for insulin resistance index(HOMA-IR, P<0.05). Serum TSH levels in the total sample were positively associated with TG after adjustment for age, sex, BMI, WHR, and HOMA-IR(β=0.088, P<0.05). Conclusion Higher serum TSH levels even within normal range seems to be a risk factor of dyslipidemia. Key words: TSH; Dyslipidemia