Abstract
Introduction: Klotho is a single-pass transmembrane protein with a long extracellular domain and short cytoplasmic tail that appears to modulate aging. Objectives: This cross-sectional investigation was conducted at a tertiary care centre to find the possible correlation of serum Klotho with various biochemical parameters in Indian chronic kidney disease (CKD) patients. Patients and Methods: The study was conducted in 80 CKD patients (58 males, 22 females). Mean age was 54.21 ± 14.08 years (25-90 years). Participants included 55 CKD- hemodialysis (HD), 10 CKD- peritoneal dialysis (PD) and 15 CKD-non-dialysis (ND) patients. Results: Serum Klotho (sKlotho) in CKD-HD patients ranged from 0 to 374.36 ng/mL with a mean of 13.76±4.3 ng/mL (median: 0.0174 ng/mL). In PD patients, sKlotho ranged from 0 to 374.36 ng/ mL with a mean of 37.58 ± 6.56 ng/mL (median of 0.0087 ng/mL). In ND population, sKlotho ranged from 0 to 7.01 ng/mL, with a mean of 0.73 ± 0.01 ng/mL (median of 0.1687ng/mL). In CKDHD and CKD-PD patients, sKlotho was positively correlated with the fibroblast growth factor 23 (pg/mL) (P<0.001). Conclusion: Serum Klotho levels show significant positive correlation with FGF23 levels in HD and PD patients. The findings of the study indicate that high Klotho and fibroblast growth factor 23 levels may be associated with worse outcomes in chronic renal failure patients.
Highlights
This cross-sectional investigation was conducted at a tertiary care centre to find the Article History: possible correlation of serum Klotho with various biochemical parameters in Indian chronic kPAiadBtnieSenyTtdsRiasnAeadCsMeT(eCtKhoDd)sp: aTthieensttsu. dy was conducted in 80 Chronic kidney disease (CKD) patients (58 males, 22 females)
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Summary
This cross-sectional investigation was conducted at a tertiary care centre to find the Article History: possible correlation of serum Klotho with various biochemical parameters in Indian chronic. LTlyheprfionsdtainteg,sloivfetrh,ebsrteuadsyt,inludnicga,taenthdactohliognh cKalnotcheor.and fibroblast growth factor 23 levels may be associated with worse outcomes in chronic renal failure patients. BLCuroenISclaomaegsnrrtcpduccalimaiaoncnnvcaccaeKteersilrcroountlhaforordhhiaseseaaelstmeheipnrgocelhidcryoa/nspircaakcptiodicwneee/yrrefduseilsaepralcashey/epmraetinideincctaasll.ceTiudhmuec-fapitnhidooisnnp:ghsatoef homeostasis, contributing to the high burden of the study indicate that high Klotho and fibroblast growth factor 23 levels may be associated with worse outcomes in chronic kidney disease patients. Please cite this paper as: Anand Y, Madhusudan V, Rajeevalochana P, Milly M, Deepu G, Georgi A. Correlation of serum soluble IKmlpotlihcoatwioitnh ffoibrrhoebalalstht gproolwictyh/pfarcatcotric2e3/rleesveealsrcinh/cmhreodnicicalkeiddnuecyadtiiosena:se patients; a single centre study. M20e2tf0o;r9m(1)i:ne,0a8.cDomOmI: 1o0n.1ly51c7o1n/sjruimp.2e0d2a0n.0ti8-.diabetic medication, has an ameliorative impact on some cancers by direct (preventing cell growth and apoptosis) and indirect (increasing insulin sensitivity) effects. There is paucity of sensitive 1maigunbaetaasml,nru1unnngieatotg-itocdddhinnmdfglon-oesgiestsmegarsmhtseefhmr(ateafe2okiegoerncmi)ette1crlno.hhgrytt9bs,niyrKet5v2remrlchtcl0eabn0oseoyans,iatantttgdhserohlittCutsekhprorpcdtaeaKaaleaerinattttiscnonDeisesieotJtdmdgteaeeunoemieasixeuiarrsnencpsriaynglrliw(ydShinettEtgtoaheistCetSwslirybhaulreKRdrnntaecdehDaDrtsieoathometal)smeahosac.retaxttnhdner-eaKlaladlgnstohoamled,CtopwtreiieohghitiKoxpnedhfhenotneDreorerKewaaieaedsnrmdlcteiosagpsmevrtiterlnheoehaldtoeu‘oroaGfrtgltlsefosuahrdioilwemtwnrugeers.gcfmdesswokiolpirIockedioanipiedm-bnnuneshpcnlnolfiaoaaaaaenfwcitnstgoicynoyocese,ndtdt,’ s(u3b)s. eqKuloetnhtoly dsuepveplroepsseeds ‘G1lαu-choypdhroaxgye’la(s1e). iInn otthheerkwidonredys, mtoetrfoegrmulainteiscathlceiummosmt reetcaobmolimsmenadnedd opraarltidcripuagtewsitihn atnhteihryepgeurlgatliyocnemoifcpparroaptheyrtrioeisdahnodrims oinnteen(dPeTdHt)hesyfnirtshtecsihsoiince for treatment recently identified type II diabetes by several lietexrpaeturtred, ieasbpeetceisalilnysitnitupteersit(o2n)e.al dialysis (PD) and nonhIenmaodddiaitlyiosnis, (wHitDh)npeaatrileyn5ts0. years of collected worldwide ODpstoemwiamanubcmtidtieeojteieedohnsoncttuitnaettctotnsiarohauvmlttelerr,lhesaeesimvextncguorpkeasodmuerdsydtrctorhiiihtfuewcneinonggadasmscgsKsae.tctmh,ulIaonomennontadheinusrtnetouhesfrsloemeteilIaardevnse,mkvaeaddeendmieinlncasiftaeenofiaeirsntwrcotmchtrafascheeoyhartKab,seort,etlironloniTtyanniitcna2hicgccrDdoooygrn,mrMeaetscntosnpiah,tdaararilmeetsolrhriiffeescnecaaotdertiifnnolleloauuostssrrrrtswwmeseei-naietifasnhetl inddoievsidnuoatlspraondduictes wcoerigrehltatgiaoinn,wainthd ivsacroiomusmboinolcyhreemlaitceadl to paarlaomwe-treisrks oinfvloolwvebdloinodcasulcgiuamr (2p)h. osphate homeostasis anOdn tehcehooctharedrihoganradp,hriecpofrintsdhinagvse. exhibited a link between increased cancer risk and diabetes in addition to adverse
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