Correlation of serum PTTG1 expression level with clinicopathological features and prognosis in patients with laryngeal cancer

Abstract

Objective:To investigate the correlation between the expression level of serum pituitary tumor transforming gene（PTTG1） and clinicopathological characteristics and prognosis in patients with laryngeal cancer. Method:Enzyme-linked immunosorbent assay was used to detect the expression of serum PTTG1 in 80 patients with laryngeal cancer and 60 patients with vocal cord polyps. The relationship between the clinicopathological characteristics of patients with laryngeal cancer and the expression of serum PTTG1 was analyzed. Cox regression analysis was used to analyze related factors affecting the prognosis of laryngeal cancer. Result:Serum PTTG1 expression level in patients with laryngeal cancer was significantly higher than that in patients with vocal cord polyps, and the difference was statistically significant（P<0.05）. The higher the lymph node metastasis, the higher the tumor TNM stage, and the lower the degree of differentiation, the higher the serum PTTG1 expression level（P<0.05）. In the prognostic survival analysis, univariate analysis showed that lymph node metastasis, tumor TNM stage, degree of differentiation, tumor diameter, and expression of PTTG1 were related to the prognosis of laryngeal cancer（P<0.01）. Cox regression multivariate showed lymph node metastasis（HR=2.651, 95%CI1.452-4.823, P=0.002）, high tumor TNM stage（HR=2.944, 95%CI1.155-6.189, P=0.026）, and low differentiation（HR=1.620, 95%CI1.133-2.169, P=0.003） and high PTTG1 expression（HR=3.511, 95%CI1.432-7.156, P<0.001） were risk factors affecting the prognosis of patients with laryngeal cancer. Conclusion:The expression level of serum PTTG1 may be closely related to the clinicopathological characteristics and prognosis of patients with laryngeal cancer, and its high expression may be one of the indicators of poor prognosis of patients with laryngeal cancer.