Abstract
PurposeTo access serum parathyroid hormone (PTH) level in elderly patients with hip fracture in relation to fracture healing outcomes.MethodsThis study included 90 elderly male patients with hip fracture and they were defined as the hip fracture group, and they were divided into healing effective group and delayed healing group by final fracture healing outcomes, 45 cases in each group; another 45 male patients older than 70 years without established osteoporosis and hip fracture were included as the control group. The levels of serum PTH level were examined in each group.ResultsSerum PTH level was significantly higher in healing effective group patients at the 7 days and 14 days after fracture than the delayed healing patients.ConclusionsOur results show that serum PTH level may be an effective indicator of hip fracture delayed healing risk in the elderly.
Highlights
The main causes of senile osteoporosis include low levels of sex hormones and reduced synthesis of bone metabolism
At the first day after fracture, serum parathyroid hormone (PTH) levels in patients with fracture have no significant difference compared with control group (Table 1); at 7 days after fracture, the level of serum PTH in patients from healing effective group was significantly higher than that of delayed healing group (p = 0.026) (Fig. 1), but there was no significant difference between each fracture group; at 14 days after fracture, the level of serum PTH in patients from healing effective group was significantly higher than
A prospective study of 32 patients with nonunion fracture healing from Kastirr et al found that 95% nonunion patients treated with PTH eventually healed after treatment [19]
Summary
The main causes of senile osteoporosis include low levels of sex hormones and reduced synthesis of bone metabolism. It has been reported that changes in serum sex hormone levels increase the risk of fracture [5]. Lack of vitamin D results in an increase in parathyroid hormone (PTH) levels, leading to bone loss [6, 7]. High bone turnover is associated with an increased risk of bone loss and associated with an increased risk of fractures [6, 8, 9] and independent of bone mineral density [6, 10,11,12]. This study examined serum PTH levels in elderly male patients with hip fracture at different times and explored its relationship with fracture healing
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