Abstract
Background: Carcinogenesis is mostly observed due to alterations in serum protein and lipid levels. Objectives: In this present study, serum protein and lipid profile are to be evaluated in OSMF patients and compared with various clinical stages of OSMF. Materials and methods: Out of 100 study subjects, 45 OSMF patients were selected as cases; 55 apparently healthy individuals were chosen as controls. The level of serum total protein, albumin, and globulin; high density lipoprotein (HDL), very low density lipoprotein (VLDL), total cholesterol (TC), triglycerides (TG), and low density lipoprotein (LDL) were measured by COBAS-6000 autoanalyzer. The obtained data were processed with an independent sample t-test. Results: Statistically significant reduction in serum total protein and albumin, LDL, HDL, TC, and TG levels were detected in all stages of OSMF patients in comparison with controls, whereas changes in serum VLDL level were not statistically significant. Conclusion: The current study showed significant alterations in serum protein and lipid profile, with advancement in the clinical stages of OSMF. In the future, the alterations in these parameters might possess a diagnostic significance and can be utilized as a biochemical indicator for the detection of neoplastic processes like OSMF.
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