CORRELATION OF SERUM GALECTIN-3 LEVELS WITH EJECTION FRACTIONS IN HEALTHY SUBJECTS AND HEART FAILURE PATIENTS

Abstract

Background: High Galectin-3 levels are indicative of severity of heart diseases and are associated with increased risk of major adverse cardiovascular events including heart failure. The objective of this study was to determine correlation between ejection fraction and serum Galectin-3 levels recorded by simple and quick test. Methods: This cross-sectional analytical study was conducted at the Armed Forces Institute of Cardiology (AFIC) Rawalpindi. Thirty (30) healthy adults and 60 heart failure patients were selected through randomised sampling. Diagnosed cases were classified using modified NYHA classification. Group 1 included healthy adults, Group 2 included 30 mild heart failure subjects of NYHA class I and II, Group 3 included 30 severe heart failure subjects of NYHA class III and IV. Ejection fraction was recorded at AFIC with trans-thoracic echocardiography in supine and left lateral positions. Blood samples of the participants were used for estimation of Galectin-3 by ELISA using human serum Galectin-3 ELISA kit Catalogue No. E1951Hu (Bio Assay technology). Observations were recorded on proforma, Pearson’s correlation test and ANOVA were performed using SPSS-24. Results: The LVEF was 70.7±2.78% in Group-1, 59.3±3.4% in Group-2, and 38.96±12.27% in Group-3. The LVEF showed a substantial negative correlation with serum Galectin-3 levels (r= -0.630, p<0.001). Conclusion: There is a significant negative correlation between Serum Galectin-3 and extent of functional changes of left ventricle recorded by Ejection fraction on echocardiography. Pak J Physiol 2022;18(2):28–30