Abstract
Objective: The objective is to investigate the correlation between post-traumatic stress disorder (PTSD) and serum cytokines in Hainan. Methods: The serum levels of IL-2, IL-4, IL-6 and IL-8 were detected by enzyme-linked immunosorbent assay (ELISA) in 60 post-traumatic stress disorder patients and 60 healthy controls in Hainan. Results: The se-rum levels of IL-2 (t = 15.981, P = 0.000), IL-6 (t = 20.984, P = 0.000) and IL-8 (t = 6.906, P = 0.000) in PTSD group were significantly higher than those in control group. There was no significant difference in serum IL-4 content be-tween the two groups (t = 1.109), P = 0.259). Conclusion: POST-traumatic stress disorder is closely related to the changes of serum cyto-kines, and IL-2, IL-6 and IL-8 may play an important role in the pathogenesis of PTSD.
Highlights
Post-traumatic stress disorder (PTSD) is a typical psychological stress disorder
POST-traumatic stress disorder is closely related to the changes of serum cytokines, and IL-2, IL-6 and IL-8 may play an important role in the pathogenesis of PTSD
Samples were taken from PTSD patients within 1 week after diagnosis, and the content of cytokines was determined by enzyme-linked immunosorbent assay (ELISA), which was produced by Shanghai Jianglai Biotechnology Co., LTD
Summary
Post-traumatic stress disorder (PTSD) is a typical psychological stress disorder. Post-traumatic stress disorder (PTSD) is a kind of post-traumatic psychological imbalance, which is a delayed and/or lasting anxiety response to unusually threatening and catastrophic events [1]. Recent studies have shown that post-traumatic stress disorder is a disease state caused by the joint involvement of the neuroendocrine system, central nervous system and immune system. In addition to major natural disasters, general man-made disasters are very common in China. According to China’s injury prevention report, injuries of various types occur about 200 million times in China every year, resulting in about 700,000 750,000 deaths, an average of 2000 people a day.
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