Correlation of serum 25-hydroxyvitamin-D3 , hs-CRP, and homocysteine in women with gestational diabetes mellitus

Abstract

IntroductionTo explore the changes and correlation of serum 25-hydroxyvitamin-D3, high-sensitivity C-reactive protein (hs-CRP), and homocysteine (Hcy) in patients with gestational diabetes mellitus (GDM).Material and methodsA total of 110 GDM patients from September 2019 to September 2020 constituted the GDM group, and 100 pregnant women with a normal 75 g oral glucose tolerance test (OGTT) throughout the same duration constituted the control group. General information of the patients was collected: maternal age, BMI, gravidity, parity, and the gestational week at the time of glucose tolerance screening. Serum levels of 25-(OH)2 -VitD3 , hs-CRP, and Hcy were compared between the two groups. Pearson correlation analysis was used to evaluate the correlation between 25-(OH)2 -VitD3 , hs-CRP, Hcy, and homeostasis model assessment of insulin resistance index (HOMA-IRI) in GDM patients.ResultsSerum 25-(OH)2 -VitD3 levels in the GDM group and control group were 15.67 ±3.62 and 18.66 ±3.41 ng/ml, hs-CRP levels were 6.07 ±1.45 and 3.12 ±1.07 mg/l, and serum Hcy levels were 17.03 ±4.10 and 8.63 ±2.27 µmol/l. Serum 25-(OH)2 -VitD3 levels in the GDM group were substantially lower than those in the control group, while hs-CRP, Hcy, and HOMA-IRI in the GDM group were significantly higher than those in the control group (p < 0.05). Pearson correlation analysis demonstrated that serum 25-(OH)2 -VitD3 levels in the GDM group were negatively correlated with HOMA-IRI. In contrast, hs-CRP and Hcy levels were substantially positively correlated with HOMA-IRI (p < 0.01).ConclusionsBlood levels of 25-(OH)2 -VitD3 , hs-CRP, and Hcy levels can be a potential indicator of GDM.