Correlation of Serum 25-Hydroxyvitamin D and Thyroid Hormones in Pregnant Women in Amman-Jordan

Abstract

1.1. Aim:The aim of this study is to investigate changes of vitamin D and thyroid hormones levels during pregnancy to maintain normal fetus development and growth. 1.2. Method: Serum hydroxyl vitamin 25(OH)D and thyroid levels were measured in109 pregnant women referred to our laboratory from prenatal clinic during the period of May to October 2015.Blood samples were detected for 25 (OH) vitamins D, TSH, FT4 and FT3by chemiluminescent(Tosoh A1A, Japan). 1.3. Results: Pregnant women aged 19-45years (18.2 years age average) were examined. The mean 25(OH) D was 21.7±5.6 ng/ml (range 8.7 to 47.2). The mean levels of Serum Free T3, FT4 and TSH were 1.61 ±0.21, ng/dl, 0.86 ±0.23 ng/dl and 1.56 ±.9 μIU/ml respectively, results for 25(OH) D mean values were 29.5 ng/ml (27.9%), 33.2 ng/ml (49.6%) and 37.3 ng/ml (22.5%) for vitamin D deficiency, insufficiency and sufficiency respectively. No correlation was found between vitamin D, TSH, FT4 and FT3 however, there was statistical significant correlation between the vitamin D and TSH (p<0.05), level especially in patients with sufficient vitamin D level. 1.4. Conclusion: Association between higher vitamin D (>30.0 ng/ml) and lower TSH in pregnant was observed (P<0.005). However, no correlation between 25-Hydroxyvitamin D FT4 and FT3 hormone was observed.