Abstract
Aim Recent studies found that levels of serum uric acid (SUA) were positively associated with serum 1,5-anhydroglucitol (1,5-AG) in subjects with type 2 diabetes mellitus (T2DM). In the current study, we investigated the association between 1,5-AG and UA in T2DM patients with different renal functions. Methods A total of 405 T2DM patients, 213 men and 192 women, participated in the study. Patients' clinical information was collected, and serum 1,5-AG, SUA, and other clinical characteristics were measured. Correlation analyses were carried out to analyze their correlation with serum 1,5-AG and SUA. Results The male group showed higher levels of SUA than the female group (282.1 ± 91.2 and 244.7 ± 71.89 μmol/L, respectively, P < 0.01). Pearson's correlation coefficients determine that SUA was positively associated with 1,5-AG in both men (r = 0.213, P < 0.05) and women (r = 0.223, P < 0.05), and such relationship can be influenced by the renal function. The positive association still existed with moderate impaired renal function. Moreover, 1,5-AG had a negative association with haemoglobin A1c (HbA1c) in T2DM subjects with eGFR ≥ 30 mL/min/1.73 m2 (P < 0.01). Conclusion The positive association between SUA and 1,5-AG still exists in T2DM with moderate renal failure. 1,5-AG can still reflect the glucose levels in patients with CKD stages 1-3.
Highlights
serum uric acid (SUA) levels tend to rise with increasing blood glucose levels in the healthy and prediabetes population, while SUA levels decline in a patient with type 2 mellitus (T2DM) [7]
The current study provides the evidence that SUA in relation to 1,5-AG in type 2 diabetes mellitus (T2DM) subjects with chronic kidney disease (CKD) stages 1-2
The negative association between haemoglobin A1c (HbA1c) and 1,5-AG still exists in T2DM patients with Estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73 m2, and 1,5-AG remains a reliable glycemic control marker
Summary
1,5-Anhydroglucitol (1,5-AG), a 1-deoxy form of glucose analog, can reflect blood glucose levels over a period of 3-7 days as well as postprandial glucose [1, 2]. The blood glucose level is above the renal threshold and reabsorption of 1,5-AG is thought to be competed with glucose causing a decline in the serum 1,5-AG level [4, 5]. 1,5-AG is still a reliable blood glucose marker in type 2 diabetic patients with chronic kidney disease (CKD) stages 1-3 [6]. SUA levels tend to rise with increasing blood glucose levels in the healthy and prediabetes population, while SUA levels decline in a patient with type 2 mellitus (T2DM) [7]. A previous study demonstrated that SUA was positively associated with 1,5-AG levels in patients with T2DM [9, 10]. We investigated the correlation between SUA and 1,5-AG using classification by a CKD disease stage in T2DM subjects
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