Correlation of salivary hs-CRP With conventional cardiovascular risk markers and hba1c in prediabetic subjects

Abstract

Prediabetes has attracted considerable attention because it increases the risk of developing diabetes and cardiovascular disease. Prediabetes is also associated with obesity and dyslipidemia. Chronic low-grade inflammation is a crucial element in the clinical course of metabolic syndrome, and cardiovascular and cerebrovascular diseases. C-Reactive Protein (CRP) is a biomarker of inflammation that tends to increase in patients with diabetes and prediabetes. Most serological markers of diabetes are detected using invasive techniques that cause anxiety and pain. Therefore, the use of noninvasive techniques for frequent biomarker monitoring is necessary. Salivary diagnostics is an upcoming field for sensitive biomarker detection, such as hs-CRP. HbA1C is a valuable glycemic risk marker and has proven to be a reliable test of time. Both HbA1C and CRP play pivotal roles in diabetes and prediabetes. hs-CRP is a measure of CRP level with greater accuracy. The lower limit of its measurement is 0.01 mg/L and the measurement is more than100 times as sensitive than the CRP measurement (lower limit 5 mg/L). Therefore, our study aimed to evaluate and establish a relationship between these factors in prediabetics. Since metabolic syndrome and prediabetes are the cause and effect of each other, correlating anthropometric measurements and lipid profile with HbA1C and hs-CRP will be our focus.