Correlation of risk categorization in gestational trophoblastic tumor between old and new combined staging and scoring system.

Abstract

To determine the correlation of risk categorization in gestational trophoblastic tumor between the revised International Federation of Gynecology and Obstetrics (FIGO) staging system combined with the original World Health Organization (WHO) scoring system, and the new FIGO staging system combined with the modified WHO scoring system. We reviewed the medical records of 124 patients with gestational trophoblastic disease seen at Songklanagarind Hospital from 1988 to 2000. All patients were classified retrospectively by the FIGO staging system (both the revised system in 1992 and the new system in 2000) and the WHO scoring system (both the original and the modified one). The correlation of risk categorization between the revised FIGO staging system combined with the original WHO scoring system (old combined system), and the new FIGO staging system combined with the modified WHO scoring system (new combined system) was studied, and the remission rates in discrepant groups were identified. The mean score was 9.7+/-5.0 (range 1-21) for the original WHO and 8.3+/-5.0 (range 1-20) for the modified WHO. The correlation of risk categorization between old and new combined systems was 97.9%. There was no patient in the low risk group as classified by the old combined system, but patients were classified as in the high risk group by the new combined system. One patient, who was in the high risk group classified by the old combined system, but in the low risk group classified by the new combined system, achieved complete remission after treatment with single agent chemotherapy. There was good correlation between the old and the new combined systems.