Abstract
The solvent selectivity triangle concept for characterizing high-performance liquid chromatographic (HPLC) mobile phase liquids consistently fails to group solvents according to selectivity for resolving aromatic compounds in reversed-phase HPLC. Selectivity differences between solvents classified in the same group often exceed those for solvents classified in different groups. Nevertheless, solvents characterized by simple relationships between resolution and 2-keto alkane retention indices correlate accurately with experimental resolution for 16 aromatic compounds with 12 reversed-phase solvents in binary mixtures with water. Also, by adjusting for the relative slopes of the 2-keto alkane retention index standards in HPLC or n-alkane standards in gas chromatography (GC), retention index differences are directly correlated with resolution, whereas nonadjusted retention index differences fail to correlate with resolution. Anomolies in McReynolds constants used in the classification of GC liquid phases are eliminated by adjustment for relative slope differences for the n-alkane standards that occur with the various phases.
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