Correlation of Renal Function with Severity of Hypoxic Ischemic Encephalopathy (HIE) in Egyptian Full Term Neonates

Abstract

Background: It is often difficult to predict which newborn with HIE will develop impaired renal function so there is an urgent need for publications about relations of severity of HIE and renal function in these infants.Aim of study: To evaluate renal function in full term neonates with HIE and its correlation with degree of HIE.Patients and methods: This case-control study was conducted on 72 full term neonates who divided into group (1) included 36 full term neonates diagnosed as HIE according to World Health Organization (WHO) definition of HIE and group (2) included 36 age- and sex-matched, full term neonates as a control group, Serum creatinine was measured at post natal age, CT scan was done for cases.Results: Serum creatinine level was elevated in first group in comparison to the control group at day 1 and day 7. It was significantly correlated to the Sarnat scoring system of HIE. The means of serum creatinine were significantly increase with the increase in severity of HIE according to Sarnat and Sarnat staging. There was statistically significant difference among serum creatinine levels regarding CT brain findings with marked elevation in serum creatinine which correlate with severity of HIE by CT brain.Conclusion: Serum creatinine level correlates with the severity of HIE.