Abstract
Background: Cardiovascular complication remains the long-term complications in spondyloarthritis (SpA). Previous studies revealed that metabolicsyndrome is the risk factor of cardiovascular in SpA patients. Previous studies also revealed that the prevalence of the metabolic syndrome is 34.9–45.7% in SpA patients. However, previous studies also revealed the controversy of the correlation of SpA’ disease activity with metabolic syndrome.Aim: The aim of the study was to investigate the correlation of SpA’ radiographical damage measured with a modified Stoke Ankylosing SpondylitisSpinal Score (mSASSS) score with metabolic syndrome in SpA patients, which routinely visited Rheumatology Outpatient Department in Dr. SoetomoGeneral Hospital.Methods: An observational study with cross-sectional design with consecutive sampling technique was conducted in July–October 2018. All SpApatients who fulfilled the inclusion criteria were included in this study. Data analysis was performed with SPSS v21.0.Results: There were 33 SpA patients (10 males and 23 females) included in this study. The average age was 48.18±12.27 years-old. The averagemSASSS score was 24,36 (K:0.93, p:0.00). Metabolic syndrome was diagnosed in 54.5% patients with 100% patients had central obesity, 66.7% hadincreased blood pressure, 61.5% had impaired fasting glucose, 55.6% had increased triglycerides, and 77.8% had decreased high-density lipoproteincholesterol. Positive correlation between mSASSS score and metabolic syndrome was observed (r:0.510, p:0.002).Conclusion: A correlation between SpA disease activity measured with mSASSS score and metabolic syndrome was observed. Therefore, routinemetabolic syndrome screening is strongly suggested for SpA patients.
Highlights
Cardiovascular complication remains the long-term complications in spondyloarthritis (SpA)
Metabolic syndrome was diagnosed in 54.5% patients with 100% patients had central obesity, 66.7% had increased blood pressure, 61.5% had impaired fasting glucose, 55.6% had increased triglycerides, and 77.8% had decreased high-density lipoprotein cholesterol
A correlation between SpA disease activity measured with modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) score and metabolic syndrome was observed
Summary
Cardiovascular complication remains the long-term complications in spondyloarthritis (SpA). Previous studies revealed that metabolic syndrome is the risk factor of cardiovascular in SpA patients. Previous studies revealed that the prevalence of the metabolic syndrome is 34.9– 45.7% in SpA patients. One of the cardiovascular risk factors is metabolic syndrome It is a constellation of obesity, insulin resistance, hypertension, and dyslipidemia [5]. Previous studies revealed that the prevalence of the metabolic syndrome is increased in SpA patients, ranging from 34.9% to 45.7% [6,7]. The mechanism remains uncertain, but it involves proinflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 which contributes to the insulin resistance, central obesity, dyslipidemia, and hypertension [8,9]
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