Abstract
To investigate the correlation of powder properties and formability of traditional Chinese medicine pellets prepared by extrusion/spheronization. The present effort was designed to evaluate the effects of the characters of powder on pellets formation by extrusion-spheronization, taking Danggui Buxue decoction extracts as a model drug and microcrystalline cellulose (MCC) as an ideal balling material for extrusion-spheronization. The diameter of powder had correlation with the plane critical angle of pellets in a certain scope and the sticky coefficient of wet mass affected roundness of pellets. Properties of powder have influence on formability of traditional Chinese medicine pellets.
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