Correlation of plasma metabolites and comorbid illnesses with poor sleep quality in patients with coronary heart disease.

Abstract

This study aimed to examine the relationship between plasma metabolites (biochemical parameters) and comorbid illnesses with sleep qualityin individuals with coronary heart disease (CHD). This descriptive cross-sectional study was conducted between 2020 and 2021 at a university hospital. Hospitalized patients with a diagnosis ofCHD were analyzed. The Personal Information Form' and Pittsburgh Sleep Quality Index (PSQI) were used to collect data. Laboratory findings including plasma metabolites were examined. Of 60 hospitalized patients with CHD, 50 (83%) had poor sleep quality. A positive and statistically significant correlation was found between the plasma metabolite blood urea nitrogen and poor sleep quality (r = 0.399; p = 0.002). The presence of CHD and additional chronic diseases (especially diabetes mellitus, hypertension, and chronic kidney disease) are important parameters associated with the risk of poor sleep quality (p = 0.040 < 0.05). Increases in blood urea nitrogen level in individuals with CHDare associated with worse sleep quality. Additional chronic diseases coexisting with CHD correlate withincreased risk of poor sleep quality.