Correlation of plasma levels of NT-proBNP and GHbA1c with severity of coronary artery disease in patients with coronary heart disease

Abstract

Objective To explore the correlation of plasma levels of NT-proBNP and GHbA1c with severity of coronary artery disease in patients with coronary heart disease. Methods A total of 130 patients with coronary heart disease examined by coronary arteriongraphy were divided into single vessel group(n=50), double vessel group (n=35) and multi-vessel group(n=45) according to severity of coronary artery disease, while 30 cases of healthy individuals were chosen as matched group.The plasma levels of NT-proBNP and GHbA1c in all these patients were measured.And the correlation of plasma levels of NT-proBNP and GHbA1c with severity of coronary artery disease were analyzed. Results (1)The levels of plasma NT-proBNP in single vessel group, double vessel group and multi-vessel group were all higher than that of matched group[(531.87±272.06) ng/L, (922.15±288.93) ng/L, (2 486.73±1 794.52) ng/L vs (47.18±26.19) ng/L](P<0.05), and the levels of plasma NT-proBNP were increased with the increase of the number of diseased vessel.(2)The levels of plasma GHbA1c in single vessel group, double vessel group and multi-vessel group were all higher than that of matched group[(6.87±0.47)%, (7.53±0.42)%, (9.65±0.51)% vs (5.49±0.32%](P<0.05), and the levels of plasma GHbA1c were increased with the increase of the number of diseased vessel.(3)By correlation analysis, the plasma levels of NT-proBNP and GHbA1c were all positively related with the number of diseased vessel(r=0.241, 0.363, P<0.05). Conclusion The plasma levels of NT-proBNP and GHbA1c were positively related with severity of coronary artery disease and they could be used as important indicators to assess the prognosis of patients with coronary artery disease. Key words: Coronary heart disease; NT-proBNP; GHbA1c; Severity of coronary artery disease; Correlation