Abstract
Introduction: Organophosphorus poisoning is one of the common causesfor the intensive care admission in the developing countries.This study was conducted to assess the correlation between Peradeniya Organophosphorus Poisoning (POP) scale and the outcomes in poisoningin a tertiary care hospital in Eastern Nepal.
 Objective: To assess the severity and outcome of OP compound poisoning with the correlation of POP score.
 Methodology: This was a prospective observational study conducted over 6 months in the intensive care unit at tertiary care hospital in the eastern part of Nepal. The study includedall OP poisoning patients presenting in the emergency department and finally admitted to intensive care unit who fulfilled the inclusion criteria.Correlation was made between POP scores and outcomes in terms of intensive care unit(ICU) stay, need of ventilation and mortality was assessed.
 Result: Fifty patients with OP poisoning wereincluded in the study. Suicide attempt was the most common reason for poisoning. The incidence of poisoning was more common among males(72%)and significant majority were aged younger than 35 years (84%). On admission, the number of patients in mild, moderate and severepoisoning group were 52%, 30% and 18% respectively. Rates for ICU stay, respiratory failure requiring ventilator and mortality was significantly (p<0.001) higher in severe POP scale.
 Conclusion: The POP scale is a useful clinical assessment tool to assess and categorize patients with OP poisoning according to severity and in predicting their clinical outcomes.
Highlights
Along with cardiovascular and respiratory emergencies acute poisoning is one of the major medical emergencies with significant morbidity and mortality
The Peradeniya Organophosphorus Poisoning (POP) scale is a useful clinical assessment tool to assess and categorize pa ents with OP poisoning according to severity and in predic ng their clinical outcomes
Various acute poisoning annually accounts for around 0.3 million people death, out of which organophosphorus poisoning alone comprises 200000 deaths, as reported by the World Health Organiza on (WHO).3,4,In 2012 an es mated 193, 460 people died worldwide from uninten onal poisoning out of which 84% occurred in lowand middle-income
Summary
Along with cardiovascular and respiratory emergencies acute poisoning is one of the major medical emergencies with significant morbidity and mortality. The inten on of most of the poisoning is to deliberate self-harm.1,2,Accidental and occupa onal exposures to the pes cides leading to acute or chronic poisoning have been seen in farmers and children. A million people die each year as a result of suicide, es mated that deliberate inges on of pes cides causes 370,000 deaths each year.[5] Rajbanshi LK et al has men oned that the incidence of organophosphorus acute poisoning was higher in the developing and resource-limitedcountries.[6]. The pes cides and insec cides containing organ ophosphorus compounds are available over the counter. This leads to the misuse of the pes cides and insec cides as poisoning substances. The mortality rate is 7.4% for appropriately treated OP poisoning in Nepal, while 10% worldwide, and 0.18% in the US.[8]
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