Correlation of NLR with Oxidative Stress Markers in Sickle Cell Anemia with Vasoocclusive Crisis

Abstract


 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 Introduction
 Sickle cell disease has long been recognized as an inflammatory condition and oxidative stress play an important role in pathophysiology of SCD. Several biomarkers have been associated with SCA clinical prognosis. This study was designed to determine the oxidative stress & inflammatory biomarker that can be used in monitoring the prognosis & management of SCA patients.
 Aim & Objective
 The present study is aimed to assess the role of NLR along with CRP, MDA and erythrocyte GSH in vaso-occlusive (HbSS) crisis patients compared to steady state (HbSS) patients.
 Materials & Method
 A total of 100 sickle cell anemia patients aged between 20–40 years of either sex were evaluated and divided into 2 groups. Group A-sickle cell anemia patients with vasoocclusive crisis(N=50) Group B-sickle cell anemia patients with steady state as control group(N=50). We analysed the oxidative stress marker i.e. reduced glutathione (GSH) & MDA along with inflammatory markers NLR, CRP and compared between both A& B groups.
 Result
 The Unpaired t test between A & B group shows significant increase in NLR, MDA, CRP Level in VOC patients as compared to steady state sickle cell patients(P?0.05). Compared with values of controls, SCA subjects with VOC had significantly lower erythrocyte GSH (P ?0.05). In the present study positive correlation of NLR with MDA and CRP in sickle cell anemia patient with vasoocclusive crisis is evaluated.
 Conclusion
 So the early prediction of vaso-occlusive crisis by the detection of the NLR count along with MDA, CRP, GSH level might be beneficial in the management sickle cell anemia patient. Additional studies are warranted to test this hypothesis.