Correlation of neutrophil lymphocyte ratio to clinical outcomes based on 6 months surveillance on traumatic brain injury patients at Haji Adam Malik General Hospital

Abstract

Introduction: Traumatic brain injury is a major cause of disability, death, and economic loss in many countries around the world. The annual incidence in the United States is reported to reach 1.7 million sufferers, in Europe it is reported as 262 per 100,000 people per year, and in Indonesia, the incidence is increasing by 1% every year. Direct and indirect damage resulting from a traumatic brain injury can cause inflammation by activating glial cells and leukocytes, inducing the release of proinflammatory cytokines, and accelerating neurodegeneration and neuroinflammation. Recently, the neutrophil-to-lymphocyte ratio (NLR) has been proposed to be a predictor of clinical outcomes for various neurological diseases such as stroke and traumatic brain injury. To put it simply, elevated NLR levels in patients with intracerebral haemorrhage were independently associated with worse clinical outcomes. Researchers want to research the relationship between NLR and outcome based on 6 months GOS in traumatic brain injury patients at Haji Adam Malik General Hospital Medan. Methods: An observational analytic study with a retrospective cohort design. Samples were selected based on inclusion and exclusion criteria from a traumatic brain injury at H. Adam Malik General Hospital Medan in 2018-2020. Results: The research data were normally distributed and analyzed by the Pearson trial; the sig value was obtained. (2-tailed) of 0.798 (P > 0.05), which means there is no between NLR and 6 months GOS outcome in traumatic brain injury patients. Conclusion: There was no relationship between NLR and outcome based on GOS 6 months of traumatic brain injury patients.