Abstract
Female mice of seven strains were studied at 3, 6, and 8 months of age for the presence of spontaneously occurring antinuclear antibodies (ANA), anti-double-stranded RNA (dsRNA) antibody and anti-single-stranded DNA (ssDNA) antibody. It was demonstrated in this report that ANA does not necessarily correlate with the presence of anti-dsRNA antibody and anti-ssDNA antibody, C57Bl and (NZB × AKR)F 1 had no ANA or antibodies to the nucleic acids. CBA H mice had positive anti-dsRNA antibody at each age studied. SJL J and AKR mice, strains with a high incidence of spontaneous neoplasia, had ANA at 6 and 8 months ( SJL J ) and anti-dsRNA antibody at 6 months (AKR). NZB and (NZB × NZW)F 1 mice which spontaneously develop autoimmune disease had positive ANA and high titer of antibodies to dsRNA and ssDNA. ssDNA was found to be the most discriminative antigen for autoimmune disease of NZB or (NZB × NZW)F 1 mice.
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