Abstract
Objective: To determine the correlation of mean pH, HCO3 and CO2 between arterial and venous blood specimens in critically ill patients.
 Study Design: Cross-sectional study.
 Place and Duration of Study: Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, from Apr to Oct 2015.
 Methodology: Forty critically ill patients admitted to the Intensive Care Unit were selected. Analysis of arterial blood gases followed by venous blood gases of the same patient was carried out after collection in lithium heparin tubes. Specimens were analyzed on COBAS 221 fully automated ABGs and an electrolyte analyzer.
 Results: Out of 40 patients, 30 (75%) were males. The average age was 57.78±7.64 years. The p-value of pH and HCO3 was 0.259 and 0.921, respectively. The CO2 in VBGs was 58.10±11.35 mm Hg versus 36.32±6.69 mm Hg in ABG, with a p-value of 0.001, which was statistically significant.
 Conclusion: In critically ill patients, pH and HCO3 levels of venous blood gases were comparable with ABG. VBG CO2 was significantly higher than ABGs.
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