Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis

Abstract

Objective: Generalized peritonitis is fairly common with very high mortality of delayed diagnosis and treatment of infectious condition. In this study, we aimed to determine the effectiveness of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and C-reactive protein (CRP) levels in peritonitis severity. Methods: This study was planned prospective and randomized. Study consisted of three groups. Each group had 50 patients. Group 1, patients with generalize peritonitis ; Group 2,patients with non-abdominal inflammatory disease; Group 3, healthy individuals as a control group. The venous blood samples from patients in group 1 and 2 were collected to determine MDA, SOD, CAT and CRP levels at the operation day. The same procedures repeated postoperative first and third day. Blood samples were collected once from group 3.One-way Anova test was used to compare average of intergroup parametric variables. Repeated Anova test was used to compare intragroup parameters. Results: Demographic features and cause of laparatomy of all groups were evaluated. MDA values of group 1 in days 0, 1st and 3rd compared with group 2 and group 3 the MDA values of group 1 were higher than group 2 and 3 (p<0,0001). CAT values of group 1 in days 0, 1st and 3rd were lower than group 2 and group 3 (p<0,0001). SOD values of group 1 and 2 in day 0 were lower than group 3 (p<0,0001). CRP values of group 1 in days 0,1st and 3rd were higher than group 2 (p<0,0001). Conclusions: It was concluded that SOD, CAT, MDA and CRP are useful parameters for the diagnosis and monitoring of generalized peritonitis severity.