Abstract
Objectives: This study set out to determine whether there are any correlations between lipid and glucose levels and oxidative stress presented by elderly patients with and without nontransmissible chronic diseases (NTCDs). Methods: Serum biochemical concentrations of lipoproteins, glucose and oxidative stress markers (malondialdehyde and nitric oxide) were determined in 44 elderly patients (22 elderly people without NTCDs and 22 elderly people with NTCDs), aged between 60 and 81 years old. Results: The elderly people with NTCDs showed higher LDL concentrations, glucose, and oxidative stress markers than those without NTCDs. There was a positive and significant correlation between the levels of malondialdehyde with the abnormal lipid profile of the elderly without NTCDs and hyperglycaemia presented by elderly people with NTCDs. The total trolox equivalent antioxidant capacity had a negative correlation with the levels of malondialdehyde in the elderly without NTCDs. Another negative correlation was observed between the levels of nitric oxide and malondialdehyde in elderly people with NTCDs. Conclusion: Once oxidative stress and abnormal lipid profile have occurred in both groups, it is suggested that the hyperglycemia present in the group with chronic diseases has been determinant for the increase of the oxidative stress found in this group.
Highlights
Nontransmissible chronic diseases (NTCDs) are the leading cause of morbidity and mortality in the world
Objectives: This study set out to determine whether there are any correlations between lipid and glucose levels and oxidative stress presented by elderly patients with and without nontransmissible chronic diseases (NTCDs)
Once oxidative stress and abnormal lipid profile have occurred in both groups, it is suggested that the hyperglycemia present in the group with chronic diseases has been determinant for the increase of the oxidative stress found in this group
Summary
Nontransmissible chronic diseases (NTCDs) are the leading cause of morbidity and mortality in the world. Among the most prevalent NTCDs are hypertension, or high blood pressure (HBP), and diabetes mellitus (DM). These diseases tend to present significantly with aging and usually when associated with comorbidities, they lead to decreased autonomy and reduced quality of life (Gottieb, Morassutti, & Cruz, 2011). Causes related to the pathogenesis of NTCDs include changes in lipid and oxidative metabolism, leading to an imbalance between the generation of reactive species (free radicals; FRs) and the ability of antioxidant defences, culminating in cell and tissue damage that have been associated with the aetiology and progression of these diseases (Gottieb, et al, 2011). In hyperglycaemia, which is another metabolic disorder commonly found in aging, increased production of oxygen FRs by the autoxidation of glucose occurs, exerting cytotoxic effects on phospholipids and contributing to the formation of MDA (Nasser, Dourado, Manjate, Carlos, & César, 2011; Valko, et al, 2007)
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