Abstract

Objective Emerging evidence supports an important role for the heme oxygenase system (HO-1) in the maintenance of a healthy pregnancy, especially during pathological challenge. HO-1 is widely accepted to be a highly sensitive and reliable marker of oxidative stress. Hence the present study was planned to analyse heme oxygenase-1 and lipid profile in maternal and cord blood venous samples of normal pregnant and preeclamptic women. Methods Fifty pregnant women were selected and grouped as group 1 (control) comprising of twenty five normotensive women immediately after delivery; group 2 (study group) comprising of age-and sex-matched twenty five preeclamptic women. Study samples were drawn (maternal venous blood and umbilical cord blood) and heme oxygenase-1 was analyzed by competitive enzyme linked immunosorbent assay and lipid profile was analyzed enzymatically. Results Cord blood hemeoxygenase-1 levels in preeclamptic women were significantly higher than those of normotensive women (p 0.05) and negatively correlated in normotensive women (r=-0.111, p>0.05), indicating the induction of HO 1 by LDL. Conclusion The findings of high serum heme oxygenase-1 levels in maternal and cord blood in preeclampsia supports the role of oxidative stress and excessive inflammatory response in the pathogenesis of preeclampsia.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.