Correlation of Ki 67, Histopathological Features and Shape of Lesionin Skeletally Mature Osteochondroma

Abstract

Background: Osteochondroma represents the most common benign tumor of bones and accounts forabout 30-50 % of them. poor information’s in previous studies act on demonstration of the significance ofatypical histological changes as a premalignant precursor in mature osteochondroma regardless of the capthickness. In this study, the proliferative activity of cartilaginous cap will be studied in skeletally maturepatients regardless of the cap thickness to demonstrate the independent significant of histological features inpredicting the malignant potential in osteochondroma.Methodology: Cases of skeletally mature osteochondroma (78 case) were isolatedand separated into sessileand pedunculated, then into G1(without suspicious histological features) and G2 (with suspicious features),and stained with Ki- 67 . Data were analyzed using SPSS version 21and p value < 0.05 was considered assignificant.Results: There was significant association between study groups and Ki 67 staining results, majority (75%)of patients with suspicious histopathological features presented with positive results of Ki 67 staining (pvalue < 0.001). while there was no correlation between shape of lesion and histopathological features (pvalue 0.662).Conclusion: A typical histopathological features can be regarded as independent factor with the otherclinical data when considering the diagnosis of grade 1 chondrosarcoma.