CORRELATION OF KI-67, BCL-2, P53 EXPRESSION WITH THE EVIDENCE OF IMMUNOHISTOCHEMICAL REACTION UNDER HERPETIC LESION IN WOMEN WITH HUMAN PAPILLOMAVIRUS OF CERVIX

Abstract

The analysis of the correlation of proliferation factor Ki-67 expression, anaptotic inhibitor bcl-2, mutant oncoprotein p53 with the evidence of immunohistochemical reaction under herpetic lesion in women with cervical HPV has been carried out under severe cervical intraepithelial neoplasia. It was established, that an evident expression of the antigens of herpes simplex virus type 2 are accompanied by the increase of proliferative activity under CIN III of cervix, whereas under a faintly evident positive reaction with herpes simplex virus type 2 a higher level of anaptotic inhibitor expression bcl-2 is observed.