Correlation of IDH1, p53 and Ki-67 immunoexpression levels with morphological, clinical prognostic parameters and preoperative/postoperative radiological findings and response to treatment in high-grade glial tumor case

Abstract

In this study, we aimed to investigate the prognostic factors affecting survival in adult patients with high-grade glial tumors. The retrospective study included 79 consecutive patients who were referred to our clinic for adjuvant radiotherapy/radiochemotherapy between 2010 and 2017. The effect of proposed prognostic factors on overall survival (OS) and disease-free survival (DFS) was evaluated with univariate and multivariate analyses. Median age was 56.63 (range, 24-84) years and the median Karnofsky Performance Status (KPS) at diagnosis was 89% (range, 50-100%). Most the cases (n=69; 87.1%)were histologically diagnosed as World Health Organization (WHO) grade IV. At a median follow-up of 12 months, OS and DFS were 12 and 8 months, respectively. Although age, KPS, IDH1, p53 and Ki-67 status were found to be statistically significant among the prognostic factors affecting OS in univariate analyses, only KPS, p53 and Ki-67 were statistically significant in multivariate analysis.In contrast, age, KPS, IDH1, and Ki-67 were found to be significant factors for DFS in univariate analysis, while only KPS and Ki-67 were found to be significant factors for DFS in multivariate analysis. KPS was the most important prognostic factor for OS and DFS. In the evaluation of postoperative histopathological findings, p53 and Ki-67 were found to be prognostic for OS while only Ki-67 was prognostic for DFS. However, IDH1, which is known as an important prognostic factor, did not have a significant prognostic value, which could be due to the limited number of cases in our study.