Correlation of hypospadias with congenital anorectal malformation in male children

Abstract

Objective To explore the correlation of hypospadias with congenital anorectal malformations in male children and to obtain more reliable data and biological materials for further research. Methods 300 male children with hypospadias treated at our hospital were selected and retrospectively analyzed. A case-control study was used to investigate the correlation of hypospadias with congenital anorectal malformation in male children. Results Hypospadias positively correlated with congenital anorectal malformation (P<0.05); and the risk causing congenital anorectal malformation in male children with hypospadias was risk 9.89 times that in those without (OR=9.00, 95% CI 4.49-18.03). Balanic hypospadias took the largest proportion, accounting for 47.33%, and perineum type the smallest, accounting for 15.33%. The incidence of congenital anorectal malformation was highest in perineum type hypospadias (68.75%), and scrotum type (21.05%), tentum type (14.42%), and balanic type (7.75%) came next; the correlation coefficient=0.353; the correlation was good and positive. Conclusion Hypospadias positively correlates with congenital anorectal malformation in male children. Children with perineum or scrotum type hypospadias has higher risk in occurring congenital anorectal malformation. There, prenatal diagnosis should be strengthened to guarantee better bearing and rearing. Key words: Male children; Hypospadias; Congenital anorectal malformation; correlation analysis