Correlation of high-sensitivity C-reactive protein with blood sugar level in patients with Type 2 diabetes

Abstract

Background: The prevalence of diabetes is rapidly rising all over the globe at an alarming rate. Complications of diabetes include microvascular and macrovascular complications. High-Sensitivity C-reactive protein (hs-CRP) is an acute phase reactant and a sensitive marker of inflammation. In addition to traditional cardiovascular risk factors, elevation in hs-CRP can be used to predict increased cardiovascular risk in diabetic patients. Aims and Objectives: This study was planned to estimate hs-CRP and fasting blood glucose (FBG) levels in diabetic and non-diabetic participants and to find out if there is any correlation between blood glucose and hs-CRP levels in diabetic and non-diabetic participants. Materials and Methods: In this study, hs-CRP and FBG levels of 120 participants were estimated. Among which 60 were diabetic, and 60 were non-diabetic participants. Participants were chosen based on inclusion and exclusion criteria. FBG was estimated by glucose oxidase peroxidase method and hs-CRP was estimated chemiluminescence immunoassay method. Data analysis were analyzed by unpaired t-test using Statistical Package for the Social Sciences Version 19.0. Results: The results of this study showed that hs-CRP increased as FBG increased. There was positive correlation seen between hs-CRP and blood glucose levels in both study and control group. Hs-CRP was seen to be much higher in diabetic participants than in non-diabetic participants. Conclusion: Thus proving that hyperglycemia itself is a factor that can cause increase of serum hs-CRP levels in Type 2 diabetic participants.