Correlation of High Eosinophil Count Levels in Blood with Metastasis in Colorectal Carcinoma

Abstract

Background: Eosinophils are bone marrow-derived granulocytes in peripheral blood and tissues primarily involved as effector cells in colorectal cancer metastasis. High levels of eosinophils correlate with poor prognosis in colorectal cancer. Aim: To prove the correlation between increased levels of eosinophils with clinical stage according to the TNM system and metastatic status in patients with colorectal carcinoma. Methods: An analytical cross-sectional study was conducted from July 2020 to June 2021 at Prof. Dr. IGNG Ngoerah Hospital. Data analysis in this study consisted of univariate analysis, bivariate analysis, and multivariate analysis using SPSS IBM version 23. Results: Obtained 40 subjects patient colorectal cancer where men were 25 (62.5%), mean age ± SD53.15 ± 12.5 years, normal nutritional status 29 (72.5%), most locations in the rectum 16 (40%), followed by descending colon 15 (37.5%), the most clinical-stage IVA 13 (32.5%), lung metastases 12 (30%) with adenocarcinoma type 34 (90%). The average level of eosinophils±SDobtained445.63±283.03. The correlation between eosinophil levels and the clinical stage is strongly positive (r = 0.604; p < 0.001), and with the incidence of distant metastases, a strong positive correlation (r = 0.651; p<0.001). Conclusion: There is a statistically significant correlation between increased levels of eosinophils in the blood in metastases and stages colorectal cancer patients, where the higher the eosinophil count levels, the higher the stage and an increase in the incidence of metastases.