Abstract
Objectives Brain single-photon emission computed tomography (SPECT) has been proposed as a potentially useful modality for the metabolic assessment of various brain tumors. Material and methods In a 10-patient prospective pilot study we evaluated whether 99mTc-Tetrofosmin ( 99mTc-TF) uptake correlates with glioma proliferative activity assessed by flow cytometric analysis. 99mTc-TF brain SPECT was performed shortly before surgical tumor excision. Results Eight patients were diagnosed with glioblastoma multiform and 2 with anaplastic astrocytoma. All tumors were aneuploid. We found a significant positive linear correlation between 99mTc-TF uptake and percentage of tumor cells on the S-phase of the cell cycle ( r = 0.92, P = 0.001). Conclusion Initial evidence suggests that 99mTc-TF could provide a non-invasive indicator of glioma proliferative activity.
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