Correlation of gene expression profiling score, cardiac hemodynamics and echocardiographic parameters in asymptomatic, rejection-free pediatric heart transplant recipients.

Abstract

To correlate gene expression profiling scores obtained by AlloMap® with cardiac hemodynamics, cardiac allograft vasculopathy (CAV), and echocardiographic parameters in asymptomatic, rejection-free pediatric heart transplant (HT) recipients. Single-institution retrospective study of 210 AlloMap scores obtained concomitantly with cardiac catheterization and echocardiogram from 55 children during follow-up after cardiac transplantation. The median age at HT was 5.1years (range, 0.9-14.1), with 29 males and 26 females. AlloMap scores were high in <2years vs ≥2years of age at the time of HT (P=.001), and trending higher with time after HT (R2 =.04, P=.004). There was no significant difference in scores between ACR grades 0 and 1R or CAV. There was mild to modest correlation of AlloMap scores with the mean right atrial pressure (P=.002), and pulmonary capillary wedge pressure (P=.02), but no correlation was found with LV SF% (P=.3), LV EF% (P=.5), or RV FAC % (P=.8). Our study provides preliminary data that the AlloMap score must be studied carefully before it can be used in children, particularly in those under 2years of age. Monitoring of serial scores for each patient could potentially reflect changes in allograft performance that may determine indications for catheterization and biopsy which needs to be validated in future studies.