Abstract
The Forkhead box (FOX) protein family includes FOXA1, and is a transcription factor (TF). It work as a pioneer factor, interacting with compressed chromatin to allow ER to bind more easily later (Nagaraj and Ma, 2021). It significantly contributed to the development and invasiveness of endocrine-resistant cells by changing the ER dependent transcriptome in numerous endocrine-resistant preclinical BC cell types (Chun et al., 2017). The present study is done during the period September 2021 and May 2022 at the University of Kufa's, Faculty of Medicine, Middle Euphrates Unit for Cancer Research. as a control group. These samples gathered from archives of the two private laboratories and re-evaluted by two pathologist. Positive nuclear IHC expression of FOXA1 is significantly reduced in 43 BC cases (58.9%) compared to 38 control persons (100%) while negative nuclear IHC expression of FOXA1 is significantly reduced in BC patients, 30 cases (41.1%) compared to 0 control persons (0.0%), Odd ratio 1.66, 95% CI (1.37-1.98), P=0.0001. Moreover, FOXA1 positivity was elevated significantly in patients with grade I and II (P=0.002) and absent of lymph node metastasis (p=0.027).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
