Correlation of ¹⁸F-FDG uptake with tumor-proliferating antigen Ki-67 expression in aggressive lymphoma

Abstract

To investigate the correlation between ¹⁸F-FDG uptake in positron emission tomography/computed tomography imaging and tumor-proliferating antigen Ki-67 expression in aggressive lymphoma. Data of ¹⁸F-FDG PET-CT imaging and immunohistochemical detection of Ki-67 expression of seventy-seven cases with initially diagnosed aggressive lymphoma were retrospectively analyzed. The intensity of ¹⁸F-FDG accumulation was determined by calculating the maximum standardized uptake value (SUVmax) and average standardized uptake value (SUVave). The average SUV at biopsy site (BxSUVave), SUVmax at biopsy site (BxSUVmax) and SUVmax at the highest tumor activity site of the body (BmSUVmax) were collected. The BmSUVmax, BxSUVmax, and BxSUVave were 13.4 ± 6.8, 11.9 ± 6.8 and 7.3 ± 4.4, respectively,and Ki-67 was (61.2 ± 20.4)% in the 77 aggressive lymphomas. The BmSUVmax was significantly higher than the BxSUVmax or BxSUVave (P < 0.05). The BmSUVmax, BxSUVmax and BxSUVave were positively correlated with the Ki-67 expression in aggressive lymphoma (P < 0.05). A positive correlation was revealed between the BxSUVmax and BmSUVmax (P < 0.05), and between the BxSUVmax and BxSUVave (P < 0.05). No significant correlation was found between the BmSUVmax or BxSUVmax and the Ki-67 in DLBCL (P > 0.05). A positive correlation was observed between the BmSUVmax or BxSUVmax and the Ki-67 expression in NK/T cell lymphoma (P < 0.05). The increasing trend of ¹⁸F-FDG uptake is correlated with the Ki-67 expression in aggressive lymphoma. The results of this study suggest that the metabolic information obtained by using BmSUVmax may help to compensate the limited sampling of histological examination at the biopsy site. Significant correlation in NK/T cell lymphoma suggests that the metabolic information from positron emission tomography-computed tomography may offer a useful parameter in the prognosis and management of this disease.