Correlation of Equol (7-Hydroxy-3-(4-Hydroxyphenyl)Chroman) in Woman Urine with the Symptoms of Menopause

Rima Yulia Effriyanti,Tita Husnitawati Madjid,Hanom Husni Syam

doi:10.4236/jbm.2016.41016

Rima Yulia Effriyanti, Tita Husnitawati Madjid + Show 1 more

Open Access

https://doi.org/10.4236/jbm.2016.41016

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Abstract

Objective: In order to identify the correlation between equol excreted through human urine and the symptom of menopause. Methods: The method used is cross sectional study examined to 99 postmenopausal women fulfilling the inclusion criteria from February 2014 to July 2014. This research was taken in the Endocrinology Clinic, Department of Obstetrics and Gynecology, Hasan Sadikin Hospital and Unpad’s Pharmacokinetic Laboratory. All objects were interviewed using menopause rating scale (MRS) questionnaire. Their urine samples were analyzed using high performance liquid chromatography (HPLC). Then the results of questionnaire and HPLC test were evaluated. Results: The result is 97 objects (98%) detected having menopausal symptoms, produced equol. There is significant correlation between the level of equol in post-menopausal women that showed correlation (－0.71) which mean the higher the equol level, the lower the MRS score (p < 0.001) that mean the symptom is milder. Conclusion: Equol level in menopause women urine is a good predictor to identify the level of menopause symptoms.

Highlights

At this time, life expectancy of women gets increased
Interviews were conducted by using a questionnaire with menopause rating scale (MRS) and the urine test is processed by using high performance liquid chromatography mass spectrophotometry (HPLC)
Statistical analysis is according to research objectives and hypotheses, namely to examine the relationship of equol (7-Hydroxy-3-(4-hydroxyphenyl)Chroman) in the urine of postmenopausal women with menopausal symptoms and to prove whether people with high levels of equol have milder menopausal symptoms or not

Summary

Introduction

Life expectancy of women gets increased. At the end of the 19th century, only 30% of women couldHow to cite this paper: Effriyanti, R.Y., Madjid, T.H. and Syam, H.H. (2016) Correlation of Equol (7-Hydroxy-3-(4-Hydroxyphenyl)Chroman) in Woman Urine with the Symptoms of Menopause. Along with the increase of health status and life expectancy of the Indonesia’s population, the number and proportion of women over 50 years old entering the menopause age continuously get increased. It is estimated to be 30.3 million or around 11.5% of the total population of Indonesia in 2020. The life expectancy of women in Indonesia is 73.38 years old, while the British is 80 years and United States is 80.93 years old [1] [2]. They will spend a third of their age at menopause and it is conceivable that their lives are haunted with metabolic problems

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Conclusion