Correlation of Endometrial Thickness and Histopathology in Women with Abnormal Uterine Bleeding

Abstract

Aim: The study was aimed to reveal endometrial thickness measured by transvaginal sonography (TVS) and various clinical factors with histopathology in women with abnormal uterine bleeding and to evaluate the accuracy of transvaginal sonography in detecting intrauterine abnormalities as compared to hysteroscopy. Methods: In this prospective study transvaginal sonography was performed in 163 women with abnormal uterine bleeding, followed within 48 hours by hysteroscopy and endometrial biopsy. Statistical analysis was performed by chi-square test and the various correlations were calculated. Results: No statistically significant association was found between endometrial thickness and cycle day with histopathology. One of the women with endometrial thickness of <5 mm had malignancy. There was a highly significant association between menstrual status and histology. Transvaginal sonography and hysteroscopy were in agreement in 79.14% of the patients. Conclusions: Based on our results, echomorphological measures can provide critical information for a conclusive diagnosis. We recommend using a combination of metric and morphological parameters when performing a sonographic assessment of the endometrium in postmenopausal women. Endometrial biopsy should be performed to exclude endometrial hyperplasia and carcinoma in postmenopausal women with endometrial bleeding to perform proper and prompt treatment, especially in old aged women.