Correlation of different Framinghan vascular risk factors and cognitive impairment

Abstract

Objective To evaluate the relationship between different Framinghan vascular risk factor and cognitive impairment in the middle-aged and elderly. Methods 71 participants from Physical Examination Center, Zhongnan Hospital of Wuhan University were consecutively recruited from March 2016 to May 2016. Framingham Cardiovascular Disease Risk Profile (FCVDRP), Framingham Stroke Risk Profile (FSRP) and Framingham Coronary Heart Disease Risk Profile (FCHDRP) were respectively used to evaluate the vascular burden of the participants. Mini-mental state examination (MMSE) and digital sign conversion test (DST) were used to evaluate the cognitive function of the participants. Partial correlation analysis was used to investigate the correlation between FCVDRP, FSRP and FCHDRP scoring methods and cognitive function. Results (1)After adjusting for education years, with the increase of vascular burden scores, the scores of MMSE (FCVDRP: low-risk group (28.29±1.38), mid-risk group(27.40±1.73), high-risk group (26.72±1.93); FSRP: low-risk group (28.00±1.60), mid-risk group (26.26±2.46), high-risk group (27.2±2.04); FCHDRP: low-risk group (27.74±1.73), mid-risk group (27.46±2.00), high-risk group (27.18±1.59)) and DST (FCVDRP: low-risk group (29.24±5.54), mid-risk group (27.40±1.73), high-risk group (26.72±6.76); FSRP: low-risk group (30.09±5.61), mid-risk group (25.11±7.55), high-risk group (23.53±5.60); FCHDRP: low-risk group (30.37±6.41), mid-risk group (25.46±6.76), high-risk group (26.82±5.99)) were significantly decreased(all P<0.05). (2)The results of partial correlations analysis showed that the scores of FSRP were significantly correlated with MMSE (r=-0.249) and DST (r=-0.291)(both P<0.05). Conclusion Aggregation of vascular risks factors may aggravate cognitive impairment in middle-aged and elderly people. Compared to FCVDRP and FCHDRP, FSRP assessment may be more significantly associated with vascular cognitive impairment. Key words: Vascular risk factors; Cognitive function; Framinghan vascular risk profile