Abstract
To obtain permeability surface (PS) values using multi-slice helical CT perfusion imaging and to evaluate the spatial distribution correlation between PS values and vascular endothelial growth factor (VEGF) expression in solitary brain metastases. Imaging was performed on 21 patients, PS values being calculated from the central, border and peripheral parts of tumours. VEGF expression was determined by immunohistochemical staining. Rim enhancement was found in 16 cases, the border of the tumour featuring PS elevation with high VEGF expression in 13 cases. In the 5 cases with nodular enhancement, the border and the central part had high permeability and VEGF expression was high in all cases, the correlation being significant (P<0.01) . VEGF expression in brain metastases positively correlates with PS values from CT perfusion imaging, so that the latter can be used in the surveillance of angiogenic activity in brain metastases.
Highlights
Brain metastases occur at any age, especially in those over the age of 40
Imaging was performed on 21 patients, permeability surface (PS) values being calculated from the central, border and peripheral parts of tumours
vascular endothelial growth factor (VEGF) expression in brain metastases positively correlates with PS values from CT perfusion imaging, so that the latter can be used in the surveillance of angiogenic activity in brain metastases
Summary
Brain metastases occur at any age, especially in those over the age of 40. The most common primary tumours are lung, breast and gastrointestinal tumours. The clinical incidence of brain metastases continues to rise, accounting for about 40% of intracranial tumours (Petchell, 2003). As a kind of tumour, the occurrence, development, invasion and metastasis of brain metastases are dependent on tumour angiogenesis. Folkman (1971) first proposed that tumour angiogenesis plays an important role in tumour biological behaviour. Studies have confirmed that tumour angiogenesis is a necessary condition for tumour growth, and has an important role in the metastasis of malignant tumours (Hanahan & Folkman, 1996). Many treatment methods control cancers by directly or indirectly affecting tumour angiogenesis, tumour growth and metastasis (O’Reilly et al, 1997; Dhanabal et al, 1999; Dixelius et al, 2000). Vascular endothelial growth factor (VEGF), which can induce tumour angiogenesis and significantly increase vascular permeability, is the strongest regulatory factor
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