Correlation of C-reactive protein with BODE index and GOLD classification in stable chronic obstructive pulmonary disease patients

Abstract

Objective To investigate the relationship between C-reactive protein(CRP) and BODE index and GOLD classification in patients with chronic obstructive pulmonary diseases(COPD) in stable phase. Methods Fifty COPD patients in stable phase were selected from November 2012 to December 2014, and the hs-CRP levels were measured, and compared with the health of the same period. The COPD patients’ GOLD classification and BODE index were evaluated, correlation analysis were executed between serum hs-CRP level and GOLD classification and BODE index including its different variables. Results The hs-CRP level in COPD patients(4.82 mg/L) was higher than that in healthy subjects(0.88 mg/L, P<0.01). The level of hs-CRP was positively correlated with BODE index(r=0.702, P<0.01) and GOLD classification(r=0.597, P<0.01). The hs-CRP level was positively correlated with MMRC(r=0.651, P<0.01), and was negative correlated with BMI(r=-0.610, P<0.01), FEV1(r=-0.713, P<0.01) and 6 min walking distance(r=-0.776, P<0.01). Conclusions hs-CRP, as an inflammatory factor, is significant higher in patients with COPD, which indicate COPD is an inflammatory disease. hs-CRP in COPD patients in stable phase is significantly correlated with GOLD classification and BODE index, including its different variables. hs-CRP has an important role in predicting and assessing disease severity and prognosis of patients with COPD. Key words: Chronic obstructive pulmonary diseases; C-reactive protein; BODE index; GOLD classification