Correlation of cognitive function and dystrobrevin binding protein 1 gene polymorphisms in patients with recurrent depressive disorder

Abstract

Objective To investigate the relationship between dystrobrevin binding protein 1(DTNBP1) gene polymorphisms and cognitive function in patients with recurrent depressive disorder. Methods 49 recurrent depressive disorder patients and 60 age-, gender- and education-matched normal controls were recruited in this case-control study.Clinical symptoms were evaluated by HAMD and Wechsler adult memory scale, Wisconsin card sorting test, trail making test(TMT), verbal fluency test (VFT), Stroop color-word test were used to evaluate cognitive function. The gene polymorphisms of DTNBP1 were determined by PCR-RFLP technique. SPSS 16.0 was used for statistical analysis. Results The distributions of genotypes in the patients and controls were consistent with Hardy-Weinberg equilibrium(P>0.05). The time in trail making A task (73.4±30.5 vs 56.2±11.7), the digital Span (9.6±2.3 vs 8.1±3.0), visual reproduction (9.6±2.3 vs 7.4±3.1), paired association learning (9.7±2.2 vs 6.1±4.2) and Spilling forward (9.1±2.4 vs 7.2±2.9) in Wechsler adult memory scale, the categories completed (1.8±1.6 vs 2.5±1.8), total trials (47.6±1.1 vs 47.3±0.7) and error numbers (28.5±5.3 vs 24.1±9.3) in WCST performs, and the word meaning interference score (18.4±9.0 vs 25.3±9.5) in Stroop color-word test were monitored.Patients with the genotype of rs9476867 G/G got higher interference number than patients with DTNBP1 rs9476867 C/G and C/C , and patients with the genotype of rs16876738 A/G spent more time to finish TMT-A than patients with rs16876738 G/G and A/A. G/G single nucleotide polymorphism (SNP) of rs9476867 and A/G SNP of rs16876738 affected attention ability. Conclusion DTNBP1 gene polymorphisms are correlated with cognitive function in recurrent depressive disorder patients. Key words: Recurrent depressive disorder; Cognition; DTNBP1; Gene polymorphisms