Abstract
The prevalence of depression among women with breast cancer (BC) is extremely variable in research studies. The aim of this study was to determine the prevalence of depressive disorder in women suffering from BC as well as to examine its relationship with clinical–pathological and immunophenotypic characteristics of BC. The study included 194 patients with BC who were diagnosed with the disease between 2009 and 2015 in the Clinical Center Kragujevac, Serbia. Pathohistological and immunohistochemical analyses was used on the material obtained after the surgical removal of breast tumors, determining all significant clinical and morphological parameters. The level of depression among the examinees confirmed that the differences in the level of depression between the histological grades were statistically significant. According to the univariate binary logistic regression, the depression of a patient correlates with the category of molecular tumor subtype/Luminal A (p < 0.0005), PR expression (p = 0.050) and lymphatic invasion (p = 0.025). Multivariate binary logistic regression showed that the onset of depression associated with the present molecular subtype of the tumor of a worse prognostic character (p = 0.019). Depression is a common disorder in women with breast cancer. The level of depression is correlates with some of the clinicоmorphological and immunophenotypic characteristics of BC.
Highlights
Breast cancer (BC) is the most common malignant tumor in women, with 458,000 deaths and 1.7 million newly diagnosed cases annually worldwide
Inclusion criteria were: women over 18; women who had signed an informed consent to participate in the study; women who had been diagnosed with breast cancer (BC) at least three weeks before conducting a self-assessment survey on depression; and the absence of other malignancy or an acute condition that would affect psychological well-being at the time of the interview
The average time elapsed since the woman had found out that she was suffering from breast cancer until the survey was 9.67 ± 14.08 months
Summary
Breast cancer (BC) is the most common malignant tumor in women, with 458,000 deaths and 1.7 million newly diagnosed cases annually worldwide. It is responsible for the cancer-related deaths in 20% of cases [1]. In Serbia, each day there are 13 new women diagnosed with breast cancer, and four of them do not survive this disease. Due to the increase in the survival rate of women affected by BC, the focus of researchers and clinicians has shifted to monitoring of the quality of life following the complex therapeutic protocols conducted in most cases [2]
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